A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 47/48 (2006.01) C07C 279/18 (2006.01) C07C 279/20 (2006.01)
Patent
CA 2338283
The present invention relates to pharmaceutical compounds which are multivalent avb3 receptor/metastasis-associated receptor ligands. The use of these multivalent ligands alone or in conjunction with other agents in pharmaceutical compositions, and in methods for treating conditions mediated by avb3 for the treatment of cancer and other angiogenic diseases, such as diabetic retinopathy, arthritis, hemangiomas, and psoriasis, are also disclosed.
La présente invention se rapporte à des composés pharmaceutiques qui sont des ligands multivalents du récepteur de a¿v?b¿3? et des récepteurs associés aux métastases. L'invention se rapporte également à l'utilisation de ces ligands multivalents, seuls ou associés à d'autres agents, dans des compositions pharmaceutiques et dans des méthodes de traitement des troubles à médiation assurée par a¿v?b¿3? permettant le traitement du cancer et d'autres maladies angiogéniques, telles que la rétinopathie diabétique, l'arthrite, les hémangiomes et le psoriasis.
Fok Kam F.
Tjoeng Foe S.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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