Multivalent human-bovine rotavirus vaccine

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/12 (2006.01) A61K 39/15 (2006.01)

Patent

CA 2336875

The present invention provides vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human x bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined in a multivalent formulation which provides a high degree of infectivity and immunogenicity without producing a transient febrile condition. Methods for producing an immunogenic response without producing a transient febrile condition are also provided.

L'invention concerne des compositions de vaccins servant à la protection contre la maladie provoquée par le rotavirus humain, et ce sans réactogénicité importante. On combine un virus humain x bovin réassorti, qui comprend chacun des quatre sérotypes VP7 les plus importants cliniquement du rotavirus humain, dans une préparation polyvalente qui présente un degré élevé d'infectivité et d'immunogénicité sans provoquer d'état fébrile transitoire. L'invention concerne également des procédés pour causer une réponse immunogène sans provoquer d'état fébrile transitoire.

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