Multivalent inhibitors of serum amyloid p component

Details Multivalent inhibitors of serum amyloid p component Multivalent inhibitors of serum amyloid p component

C - Chemistry, Metallurgy

07

D

C07D 319/06 (2006.01) A61K 31/357 (2006.01)

Patent

CA 2525302

Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are useful for treating amyloidosis and diseases associated with amyloidosis, for example Alzheimer&supl;s disease and maturity onset diabetes mellitus.

La présente invention concerne l'élaboration de nouveaux dérivés de pyruvate cyclique du glycérol. Ces dérivés se sont avérés capables d'inhiber la liaison d'un dérivé de proline D avec une composante P d'amyloïdes sériques (SAP). En l'occurrence, les composés de l'invention conviennent au traitement de l'amyloïdose et des affections liées à l'amyloïdose telles que la maladie d'Alzheimer et le diabète de type 2.

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