Multivalent meningococcal derivatized polysaccharide-protein...

A - Human Necessities – 61 – K

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A61K 39/385 (2006.01) A61K 39/02 (2006.01) A61K 39/095 (2006.01) A61K 39/116 (2006.01) C07H 1/00 (2006.01)

Patent

CA 2577920

The present invention describes derivatized polysaccharide-protein conjugates, a composition comprising one or more of such derivatized polysaccharide- protein conjugates and methods of immunizing human patients with the same. The derivatized polysaccharide-protein conjugates are purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y, derivatized chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains.

La présente invention a trait à des conjugués polysaccharide/protéine dérivatisés, à une composition comportant un ou plusieurs conjugués polysaccharide/protéine dérivatisés et à des procédés d'immunisation de patients humains avec ceux-ci. Les conjugués polysaccharide/protéine dérivatisés sont des polysaccharides capsulaires dérivés de sérogroupes A, C, W-135, et Y dérivatisés de Neisseria meningitidis chimiquement activés et fixés de manière sélective à une protéine porteuse au moyen d'une liaison chimique covalente, formant des conjugués polysaccharide/protéine capables de déclencher une immunité de longue durée contre une variété de souches de N. meningitidis.

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