A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/095 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2524860
The present invention describes derivatized polysaccharide-protein conjugates, a composition comprising one or more of such derivatized polysaccharide- protein conjugates and methods of immunizing human patients with the same. The derivatized polysaccharide-protein conjugates are purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y, derivatized, chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains.
L'invention concerne des conjugués dérivatisés de polysaccharides-protéines, une composition contenant un ou plusieurs de ces conjugués et des méthodes d'immunisation de patients humains au moyen de ces derniers. Ces conjugués consistent en des polysaccharides capsulaires purifiés provenant de sérogroupes A, C, W-135, Y de Neisseria meningitidis, dérivatisés, activés chimiquement et fixés de façon sélective à une protéine porteuse au moyen d'une liaison chimique covalente, ce qui permet l'obtenir des conjugués de polysaccharides-protéines capables de conférer une immunité à long terme à une variété de souches de N. meningitidis.
Ryall Robert P.
Aventis Pasteur Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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