A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 39/095 (2006.01)
Patent
CA 2435681
The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacterial Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults.
La présente invention concerne un vaccin combiné qui offre une large protection contre une maladie méningococcique causée par les bactéries pathogènes Neisseria meningitidis. Le vaccin est constitué de quatre conjugués de polysaccharide et de protéine, sous forme de préparation vaccinale à dose unique. Des polysaccharides capsulaires purifiés issus de sérogroupes A, C, W-135 et Y de Neisseria meningitidis sont activés chimiquement et couplés sélectivement à une protéine porteuse, par une liaison chimique covalente, afin de former des conjugués de polysaccharide et de protéine capables de déclencher une immunité durable dans un grand nombre de souches de N. meningitidis chez les enfants tout comme chez les adultes.
Ryall Robert P.
Aventis Pasteur
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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