Multivalent metal salts of boronic acids for treating...

A - Human Necessities – 61 – K

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A61K 31/69 (2006.01) C07D 207/08 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2535788

Salts of a pharmaceutically acceptable divalent metal and an organoboronic acid drug. Examples of such metals are calcium, magnesium and zinc. The organoboronic acid drug may be a boropeptide protease inhibitor. The salts may be formulated in oral dosage form. The salts are used in the manufacure of oral medicaments for treating thrombosis.

L'invention concerne des sels d'un métal divalent pharmaceutiquement acceptable et un médicament d'acide organoboronique. Des exemples de ces métaux sont le calcium, le magnésium et le zinc. Le médicament d'acide organoboronique peut être un inhibiteur de la protéase boropetidique. Les sels peuvent entrer dans une composition sous forme de dosage par voie oral. Les sels sont utilisés dans la production de médicaments administrés par voie orale de traitement de la thrombose.

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