Multivalent neuraminidase inhibitor conjugates

Details Multivalent neuraminidase inhibitor conjugates Multivalent neuraminidase inhibitor conjugates

C - Chemistry, Metallurgy

07

D

C07D 407/14 (2006.01) A61K 31/351 (2006.01) A61K 31/496 (2006.01) A61P 31/16 (2006.01) C07D 309/28 (2006.01) C07D 405/14 (2006.01) C07D 493/04 (2006.01) C12Q 1/04 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2416336

The invention relates to a multimeric compound or a pharmaceutically acceptable salt or derivative thereof which comprises three or more neuraminidase-binding groups attached to a spacer or linking group, in which the neuraminidase-binding group is a compound which binds to the active site of influenza virus neuraminidase, but is not cleaved by the neuraminidase. The invention also relates to processes for the preparation of the multimeric compound defined above, pharmaceutical compositions containing them or methods for the treatment and/or prophylaxis of a viral infection involving them.

L'invention concerne un composé multimère ou un sel ou un dérivé pharmaceutiquement acceptable de ce dernier, qui comprend trois ou plusieurs groupes de liaison à la neuraminidase liés à un groupe de liaison ou espaceur. Ce groupe de liaison à la neuraminidase est un composé qui se lie au site actif de la neuraminidase du virus de la grippe mais n'est pas coupé par la neuraminidase. L'invention traite également de procédés pour la préparation du composé multimère défini plus haut, de compositions pharmaceutiques à base de ces composés ou de procédés pour le traitement et/ou la prophylaxie d'une infection virale impliquant ces composés.

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