Multivalent salts of pyridostigmine and related compounds

Details Multivalent salts of pyridostigmine and related compounds Multivalent salts of pyridostigmine and related compounds

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) C07C 271/42 (2006.01) C07C 271/56 (2006.01) C07C 271/58 (2006.01) C07D 213/65 (2006.01) C07D 239/34 (2006.01) C07D 401/08 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 407/06 (2006.01) C07D 407/08 (2006.01) C07D 407/10 (2006.01) C07D 407/12 (2006.01)

Patent

CA 2271786

A quaternary ammonium cholinergic agent is complexed with a multivalent anion, or with multiple monovalent anions. The complex may be administered orally to a patient to treat pain, or for some other purpose. Numerous modifications are contemplated, including modifications to the ring structure of the compound, substitution and functionalization of the ring. Other contemplated modifications include the use of different anions, including various monovalent and polyvalent anions, and both organic and inorganic anions. The compounds have utility as cholinergic agents, and especially in the treatment of mysasthenia gravis, chest pain, and carpal tunnel syndrome.

L'agent concerne un agent cholinergique d'ammonium quaternaire formant un complexe avec un anion multivalent ou avec plusieurs anions monovalents. Le complexe peut être administré par voie orale à un patient pour traiter une douleur, ou dans un autre but. De nombreuses modifications sont possibles, y compris des modifications apportées à la structure cyclique du composé, la substitution et la fonctionnalisation du noyau. D'autres modifications consistent en l'utilisation de différents anions, y compris plusieurs anions monovalents et polyvalents, ainsi que des anions organiques et des anions inorganiques. Les composés peuvent servir comme agents cholinergiques, notamment dans le traitement de la myasthénie grave, la douleur thoracique et le syndrome du canal carpien.

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