Multivalent vaccine composition

A - Human Necessities – 61 – K

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A61K 39/385 (2006.01) A61K 39/095 (2006.01) A61K 39/102 (2006.01) A61K 39/116 (2006.01) A61K 39/13 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01)

Patent

CA 2412497

A multi-valent vaccine composition is described comprising a conjugate of the capsular polysaccharide of H. influenzae b not adsorbed onto an aluminium adjuvant salt, and two or more further bacterial polysaccharides. A multi- valent vaccine composition is also described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, Hepatitis B surface antigen, a conjugate of the capsular polysaccharide of H. influenzae b, and a conjugate of a capsular polysaccharide of N. meningitidis type A or C (or both). Furthermore, a multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.

La présente invention concerne une composition vaccinale polyvalente qui comprend un conjugué du polysaccharide capsulaire de H.influenzae b non adsorbé sur un sel d'adjuvant à l'aluminium et au moins deux autres polysaccharides bactériens; une composition vaccinale polyvalente comprenant un constituant de la coqueluche à cellules entières, une anatoxine tétanique, une anatoxine diphtérique, un antigène de surface de l'hépatite B, un conjugué du polysaccharide capsulaire de H.influenzae b et un conjugué d'un polysaccharide capsulaire de N. meningitidisde type A et/ou C ; une composition vaccinale polyvalente comprenant un constituant de la coqueluche à cellules entières, une anatoxine tétanique, une anatoxine diphtérique et une faible dose d'un conjugué du polysaccharide capsulaire de H.influenzaeb.

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