Multivalent vaccines based on papaya mosaic virus and uses...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/112 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) A61P 31/14 (2006.01) A61P 31/16 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2742288

A multivalent vaccine composition that comprises a papaya mosaic virus (PapMV) component and one or more antigens is provided. The composition can further optionally comprise a Salmonella spp. porin component. The PapMV component can be PapMV or PapMV virus-like particles (VLPs). The porin component can be a Salmonella spp. OmpC, OmpF or a combination thereof, and can be combined with the PapMV component or conjugated to the PapMV component. The PapMV component in the multivalent vaccine composition functions as an adjuvant and/or an immunostimulant with respect to the one or more antigens. Use of the multivalent vaccine compositions to provide protection against a plurality of strains of a pathogen, or against more than one pathogen, are also provided.

L'invention porte sur une composition de vaccins multivalents qui renferme un composant de virus mosaïque de la papaye (PapMV) et un ou plusieurs antigènes. La composition peut en outre éventuellement renfermer un composant porine de Salmonella spp. Le composant PapMV peut être des particules de PapMV ou de type virus PapMV (VLP). Le composant porine peut être un OmpC, OmpF de Salmonella spp. ou une combinaison correspondante, et peut être combiné avec le composant PapMV ou conjugué au composant. Le composant PapMV dans la composition de vaccin multivalent fonctionne en tant qu'adjuvant et/ou immunostimulant par rapport au ou aux antigènes. L'invention porte également sur l'utilisation des compositions de vaccin multivalent pour fournir une protection contre une pluralité de souches d'un pathogène, ou contre plus d'un pathogène.

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