Multivariate random search method with multiple starts and...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2478022

The present invention provides multivariate methods for analyzing microarray gene expression data of high dimensional space and thereby identifying differentially expressed genes. The methods of this invention provide a random search procedure with multiple starts and early stop. Larger sets of differentially expressed genes may be identified using the methods of this invention starting from feature spaces of smaller dimensionality where accurate estimates on covariance matrix can be made.

L'invention porte sur des procédés multivariés permettant d'analyser des données d'expression génique de microréseaux d'espace dimensionnel élevé et, par conséquent, d'identifier des gènes exprimés de manière différentielle. Ces procédés fournissent un procédé de recherche aléatoire à démarrages multiples et à arrêt prématuré. Des ensembles plus grands de gènes exprimés de manière différentielle peuvent être identifiés au moyen de ces procédés à partir des espaces des attributs à mode dimensionnel réduit dans lesquels des estimations précises sur des matrices de covariances peuvent être effectuées.

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