Muramyl compounds for treatment of septic shock

Details Muramyl compounds for treatment of septic shock Muramyl compounds for treatment of septic shock

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 38/14 (2006.01)

Patent

CA 2123912

Muramyl peptide compounds which: (a) are non-pyrogenic; and/or (b) ameliorate endotoxin-induced weight loss and/or hypophagia; and/or (c) reduce TNF production; and/or (d) stimulate macrophages to process endotoxin are useful, in the treatment of septic shock; cachexia and other life-threatening inflammatory conditions. Preferred compounds include N-acetyl-gluco-saminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) and N- acetyl-glucosaminyl-N-acetyl-muramyl-L-alanyi-D-glutamic acid (GMDP-A).

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