Muramyl dipeptide derivatives

Details Muramyl dipeptide derivatives Muramyl dipeptide derivatives

C - Chemistry, Metallurgy

07

K

167/129, 530/9,

C07K 9/00 (2006.01) A61K 38/14 (2006.01) A61K 39/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2019922

900-9576 A B S T R A C T : MURAMYL DIPEPTIDE DERIVATIVES The 3-0-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl- sn-glycerol derivative of formula I Image I wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly indicated for use as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises. It is obtained by deprotection of a corresponding compound having one or more hydroxy groups(s) in protected form. 6300/VA 1446 VASP13/VASP23

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