Muramyldipeptide derivatives

Details Muramyldipeptide derivatives Muramyldipeptide derivatives

C - Chemistry, Metallurgy

07

K

530/9

C07K 9/00 (2006.01)

Patent

CA 1183128

ABSTRACT OF THE DISCLOSURE Muramyldipeptide derivatives of the formula (I): Image (I) wherein X represents an amino acid residue such as of L-alanine, L-serine, L-valine, glycine, etc , and Y represents a group -NH-A or Image -NHCO-A wherein R1 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a carboxamide group or a carboxyl group, n represents an integer of 1 to 6 , A re- presents a straight or branched chain, saturated or unsaturated aliphatic hydrocarbon residue of 7 to 30 carbon atoms, and "Acyl" means an acyl group of an aliphatic carboxylic acid having 2 to 6 carbon atoms. These compounds have excellent adjuvant activity and/or prophylactic and therapeutic effects against microbial infections.

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