Muramyldipeptide derivatives and influenza vaccine...

Details Muramyldipeptide derivatives and influenza vaccine... Muramyldipeptide derivatives and influenza vaccine...

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 39/145 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2054228

Abstract of the Disclosure Novel murarnyldipeptide derivatives such as [6-0-(2- tetradecylhexadecanoyl)-N--acetylmuramoyl]-L-alanyl-D-glutamamide and [6-0-(2-tetradecylhexadecanoyl)-N-acetylmuramoyl]-L-alanyl-N -methyl- D-glutamamide are provided. The muramyldipeptide derivatives are excellent compound as an adjuvant or a constituting component of virosome vaccine. An influenza vaccine comprises a complex of the muramyldipeptide derivative and an influenza virus antigen. The influenza vaccine has excellent antibody-producing capacity and safety.

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