C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C07K 16/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2219775
A partial murine cDNA clone, a human cDNA clone, and a partial human genomic clone, each encoding a Box-dependent myc-interacting polypeptide termed Bin1, are provided. Also provided are methods of using the nucleic acid sequences, polypeptides, and antibodies directed against same in the diagnosis and treatment of cancers and hyperplastic disease states.
L'invention décrit un clone d'ADN complémentaire murin partiel, un clone d'ADN complémentaire humain et un clone génomique partiel humain, chacun codant un polypeptide, appelé Bin1, interagissant avec myc et dépendant des boîtes. Elle décrit également des procédés permettant d'utiliser les séquences nucléotidiques, polypeptides et anticorps dirigés contre ces derniers dans le diagnostic et le traitement de cancers et d'états pathologiques hyperplasiques.
Prendergast George C.
Sakamuro Daitoku
Gowling Lafleur Henderson Llp
The Wistar Institute Of Anatomy And Biology
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