Murine model for human carcinoma

Details Murine model for human carcinoma Murine model for human carcinoma

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/30 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2305643

A murine model for human breast, ovarian and prostate cancer is provided. The model comprises either an immunodeficient mouse containing human primary breast, ovarian or prostate carcinoma tissue implanted within the gonadal fat pad, or an immunodeficient mouse containing human prostate or ovarian carcinoma tissue subcutaneously implanted therein. Methods of using the murine model, for example, to grow tumors and to screen treatments for breast, ovarian and/or prostate cancer are also provided.

L'invention se rapporte à un modèle murin associé au cancer du sein, des ovaires et de la prostate chez l'être humain. Ce modèle est composé d'une souris immunodéficiente chez laquelle a été implanté dans le coussinet adipeux gonadique un tissu de carcinome associé à un cancer primitif du sein, des ovaires ou de la prostate, ou une souris immunodéficiente chez laquelle a été implanté de manière sous-cutanée un tissu de carcinome humain de la prostate ou des ovaires. L'invention se rapporte à l'utilisation de ce modèle murin pour, par exemple, faire se développer des tumeurs et pour sélectionner des traitements pour le cancer du sein, des ovaires et/ou de la prostate.

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