Murine model for human carcinoma

Details Murine model for human carcinoma Murine model for human carcinoma

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2237300

A murine model for human breast, ovarian and prostate cancer is provided. The model comprises either an immunodeficient mouse containing human primary breast or ovarian carcinoma tissue implanted within the gonadal fat pad, or an immunodeficient mouse containing human prostate carcinoma tissue subcutaneously implanted therein. Methods of using the murine model, for example, to grow tumors and to screen treatments for breast, ovarian and/or prostate cancer are also provided.

L'invention concerne un modèle murin pour la croissance du cancer humain du sein, de l'ovaire et de la prostate. Ce modèle peut être soit une souris immunodéficiente contenant des tissus de cancer primaire humain du sein ou de l'ovaire implantés dans le coussinet adipeux ovarien, soit une souris immunodéficiente contenant des tissus du cancer humain de la prostate implantés sous la peau. L'invention concerne également l'utilisation de ce modèle murin, par exemple pour la croissance de tumeurs et pour la sélection de traitements du cancer du sein, de l'ovaire du sein et/ou de la prostate.

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