C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/12 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 5/18 (2006.01) C12N 5/20 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/58 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2239799
The present invention provides a monoclonal anti-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody I1D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG-associated tumors.
L'invention concerne un anticorps monoclonal anti-idiotype 11D10 provoquant une réaction immunitaire contre un déterminant antigénique spécifique d'une mucine à poids moléculaire élevé de globule de matières grasses du lait maternel (HMFG), ainsi qu'un hybridome produisant 11D10. L'hybridome produisant 11D10 a été sélectionné au moyen de procédés spécifiques. 11D10 provoque une réaction immunitaire contre HMFG chez la souris, le lapin, le singe et chez les malades présentant des tumeurs évoluées associées à HMFG. L'invention concerne des compositions obtenues au moyen de séquences de polynucléotides codant les régions variables légères ou lourdes de l'anticorps monoclonal anti-idiotype 11D10, ainsi que des polypeptides codés par lesdites séquences. L'invention concerne également des compositions qu'on peut utiliser dans la détection ou le traitement de tumeurs associées à HMFG.
Chatterjee Malaya
Chatterjee Sunil K.
Foon Kenneth A.
Borden Ladner Gervais Llp
The University Of Kentucky Research Foundation
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