Murine stem cells and applications thereof

Details Murine stem cells and applications thereof Murine stem cells and applications thereof

A - Human Necessities

01

K

A01K 67/027 (2006.01) C12N 15/12 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2607859

The invention relates to animal solid tumour models which comprise a transgenic non-human mammal containing in its genome a DNA construct that comprises a gene created and/or activated by a genetic anomaly associated with human cancer operatively bound to a promoter that directs the expression of the gene in Scal+ cells. The invention also relates to stem cells capable of specifically expressing in stem cells human genetic anomalies associated with human pathologies. Applications of these models and stem cells, such as diagnostic, therapeutic and prophylactic applications for human diseases, and products and methods are provided.

L'invention concerne des modèles de tumeurs solides animales comprenant un mammifère non humain transgénique contenant dans son génome une construction d'ADN contenant un gène créé et/ou activé par une anomalie génétique associée au cancer humain, lié fonctionnel à un promoteur qui dirige l'expression du gène dans des cellules Sca1+. L'invention concerne également des cellules souches aptes à exprimer spécifiquement dans des cellules souches des anomalies génétiques humaines associées à des pathologies humaines. L'invention concerne encore des applications de ces modèles et cellules souches, telles que des applications diagnostiques, thérapeutiques et prophylactiques pour des maladies humaines, ainsi que des produits et méthodes associés.

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