Muscarinic antagonists with parp and sir modulating activity...

Details Muscarinic antagonists with parp and sir modulating activity... Muscarinic antagonists with parp and sir modulating activity...

A - Human Necessities

61

K

A61K 31/5513 (2006.01) A61K 31/5517 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01) A61P 1/04 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/08 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2573673

The present invention relates to generally to the cytoprotective activity of mixed muscarinic inhibition/PARP modulation and in particular to the use of dual inhibitors of M1 muscarinic receptor and poly(ADP-ribose) polymerase (PARP) as neuroprotective medicaments, particularly as medicaments for the prevention and/or treatment of neurological diseases. Particularly preferred compounds are condensed diazepinones, e.g. condensed benzodiazepinones such as pirenzepine or compounds which are metabolized to condensed benzodiazepinones such as olanzapine.

De façon générale, La présente invention concerne l'activité cytoprotectrice d'une inhibition muscarinique/modulation PARP mixtes et en particulier l'utilisation d'inhibiteurs doubles du récepteur muscarinique M1 et de la poly(ADP-ribose) polymérase (PARP) en tant que médicaments neuroprotecteurs pour la prévention et/ou le traitement de troubles neurologiques. Sont de loin préférables des composés de diazépinones condensés, c'est-à-dire des benzodiazépinones condensés tels que la pirenzépine ou des composés qui sont métabolisés en benzodiazépinones condensés tels que l'olanzapine.

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