Muscarinic receptor antagonists

Details Muscarinic receptor antagonists Muscarinic receptor antagonists

C - Chemistry, Metallurgy

07

C

167/179, 260/599

C07C 217/60 (2006.01) A61K 31/135 (2006.01) C07C 217/10 (2006.01) C07C 217/52 (2006.01) C07C 217/56 (2006.01) C07C 225/16 (2006.01) C07C 229/38 (2006.01) C07C 237/32 (2006.01) C07C 255/58 (2006.01) C07C 311/05 (2006.01) C07C 311/08 (2006.01) C07C 311/37 (2006.01) C07D 307/79 (2006.01) C07D 317/58 (2006.01) C07D 319/18 (2006.01) C07D 333/20 (2006.01) C07D 337/12 (2006.01)

Patent

CA 1337193

A muscarinic receptor antagonist, useful in treating irritable bowel syndrome, of the formula:- Image --- (I) or a pharmaceutically acceptable salt thereof, wherein R1 is a group of the formula:- or Image Image where Z and Z1 are each independently hydrogen, halo or C1-C4 alkyl; is -(CH2)2-, -CH=CH-, -CH2-S-, -CH2-O-, -S- or -O-; Y is a direct link, O or S; R2 and R3 are each independently C1-C4 alkyl or together represent -(CH2)p- where p is 2, 3, 4 or 5; R4 is H or C1-C4 alkyl; m is 1, 2 or 3, with the proviso that when m is 1, Y is a direct link; and R is a group of the formula:- Image , Image , Image or Image where either R5 and R6 are certain specified optional substituents, or R5 and R6, when attached to adjacent carbon atoms, together represent a group of the formula -O(CH2)rO- where r is 1, 2 or 3, -O(CH2)2- or -(CH2)3-; R7 is H, C1-C4 alkyl or -CONH2; and R8 is H, C1-C4 alkyl or C1-C4 alkoxy.

615037

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