Muscarinic receptor antagonists

Details Muscarinic receptor antagonists Muscarinic receptor antagonists

A - Human Necessities

61

K

A61K 38/00 (2006.01) A01N 43/00 (2006.01) A01N 55/02 (2006.01) A61K 31/135 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/445 (2006.01) A61K 31/45 (2006.01) A61K 31/4523 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/455 (2006.01) A61K 31/498 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 51/00 (2006.01) A61P 1/04 (2006.01) A61P 1/06 (2006.01) A61P 11/00 (2006.0

Patent

CA 2315883

Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.

L'invention concerne des composés à liaisons multiples, lesquels composés sont des antagonistes des récepteurs muscariniques. Les composés à liaisons multiples de l'invention renferment entre 2 et 10 ligands fixés de manière covalente à une ou plusieurs séquences de liaison. Chaque ligand est, indépendamment des autres, un antagoniste des récepteurs muscariniques ou un modulateur allostérique, à condition qu'un des ligands au moins soit un antagoniste des récepteurs muscariniques. Les composés à liaisons multiples de l'invention sont utiles dans le traitement et la prévention de maladies telles que la broncho-pneumopathie chronique obstructive, la bronchite chronique, la colopathie fonctionnelle, l'incontinence urinaire, etc..

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