C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/14 (2006.01) A61K 31/4164 (2006.01) A61K 31/4439 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) C07D 233/60 (2006.01) C07D 233/61 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2635335
Compounds of Formula (I), wherein represents a single bond when G is -OH and double bond when G is -O; R1 and R2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl or heteroarylalkyl; R3 is selected from the group selected from hydrogen, hydroxy, alkoxy, alkenyloxy or alkynyloxy; X is selected from oxygen, -NH, -NR (wherein R is alkyl, alkenyl, alkenyl, alkynyl or aryl), sulphur or no atom; Het is heterocyclyl or heteroaryl; n is an integer from 1 to 6; are muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and 4 i gastrointestinal systems mediated through muscarinic receptors.
La présente invention concerne de manière générale des antagonistes des récepteurs muscariniques qui sont utiles entre autres pour le traitement de diverses maladies des systèmes respiratoire, urinaire et gastro-intestinal médiées par les récepteurs muscariniques. L'invention concerne également le procédé de préparation des composés présentés, de compositions pharmaceutiques contenant ces composés, ainsi que les procédés de traitement de maladies médiées par les récepteurs muscariniques.
Bhatt Beenu
Chugh Anita
Gupta Suman
Jindal Shelly
Kaur Jaskiran
Dimock Stratton Llp
Ranbaxy Laboratories Limited
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