Muscarinic receptor antagonists

Details Muscarinic receptor antagonists Muscarinic receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/34 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 207/08 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) E21B 29/06 (2006.01)

Patent

CA 2067817

2067817 9110647 PCTABS00006 Muscarinic receptor antagonists, particularly useful in the treating of irritable bowel syndrome, of formula (I), and their pharmaceutically acceptable salts, wherein R is -CN or -CONH2; and R1 is a group of formula (a), (b), (c) or Het, where R2 and R3 are each independently H, C1-C4 alkyl, C1-C4 alkoxy, -(CH2)qOH, halo, trifluoromethyl, -(CH2)qNR4R5, -SO2NH2, or -(CH2)qCONR4R5; R4 and R5 are each independently H or C1-C4 alkyl; q is 0, 1 or 2; r is 1, 2 or 3; X and X1 are each independently O or CH2; m is 1, 2 or 3; n is 1, 2 or 3, with the proviso that when the group -(CH2)m- is attached to the 3-position of the piperidine or pyrrolidine ring, n is 2 or 3; p is 0 or 1; and "Het" is pyridyl, pyrazinyl or thienyl.

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