Muscle cells and their use in cardiac repair

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/00 (2006.01) C12N 5/073 (2010.01) C12N 5/077 (2010.01) A61K 35/12 (2006.01) A61K 35/54 (2006.01)

Patent

CA 2479582

Muscle cells and methods for using the muscle cells are provided. In one embodiment, the invention provides transplantable skeletal muscle cell compositions and their methods of use. In one embodiment, the muscle cells can be transplanted into patients having disorders characterized by insufficient cardiac function, e.g., congestive heart failure, in a subject by administering the skeletal myoblasts to the subject. The muscle cells can be autologous, allogeneic, or xenogeneic to the recipient.

L'invention concerne des cellules musculaires et des procédés d'utilisation de ces cellules musculaires. Dans un mode de réalisation, l'invention concerne des compositions de cellules musculaires du squelette pouvant être transplantées ainsi que leurs procédés d'utilisation. Dans un autre mode de réalisation, les cellules musculaires peuvent être transplantées chez des patients présentant des troubles caractérisés par une fonction cardiaque insuffisante, par ex. une insuffisance cardiaque congestive, par administration des myoblastes du squelette à un sujet. Les cellules musculaires peuvent être autologues, allogéniques, ou xénogéniques par rapport au receveur.

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