Muscle cells and their use in cardiac repair

Details Muscle cells and their use in cardiac repair Muscle cells and their use in cardiac repair

C - Chemistry, Metallurgy

12

N

C12N 5/06 (2006.01) A61K 35/34 (2006.01) A61P 43/00 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2378643

Muscle cells and methods for using the muscle cells are provided. In one embodiment, the invention provides transplantable skeletal muscle cell compositions and their methods of use. In one embodiment, the muscle cells can be transplanted into patients having disorders characterized by insufficient cardiac function, e.g., congestive heart failure, in a subject by administering the skeletal myoblasts to the subject. The muscle cells can be autologous, allogeneic, or xenogeneic to the recipient.

L'invention concerne des cellules musculaires et leurs méthodes d'utilisation. Dans un mode de réalisation, l'invention concerne des compositions de cellules musculaires du squelette transplantables et leurs procédés d'utilisation. Dans un autre mode de réalisation, les cellules musculaires peuvent être transplantées dans des patients présentant des troubles caractérisés par une fonction cardiaque insuffisante, par exemple une insuffisance cardiaque globale, par l'administration de myoblastes squelettiques audit sujet. Les cellules musculaires peuvent être autologues, allogéniques ou xénogéniques par rapport au receveur.

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