C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) A61K 35/34 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2673117
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.
L'invention porte sur des cellules progénitrices tirées de muscles qui présentent une survie à long terme suite à une transplantation dans des tissus corporels et qui peuvent augmenter la masse de tissus mous après leur introduction (par exemple par injection, transplantation, ou implantation) dans un site de tissus mous. L'invention porte également sur des méthodes d'isolement desdites cellules et des méthodes permettant de modifier génétiquement lesdites cellules en vue d'une thérapie de transfert de gènes. L'invention porte en outre sur des méthodes d'utilisation de compositions comprenant lesdites cellules pour augmenter et gonfler des tissus mous de mammifères, dont l'homme et traiter ses situations cosmétiques ou fonctionnelles diverses, y compris les malformations, blessures, faiblesses, maladies, ou dysfonctionnements. L'invention porte en particulier sur des traitements et l'amélioration de symptômes relatifs aux pathologies gastro-oesophagiennes telles que le reflux gastro-oesophagien.
Chancellor Michael B.
Jankowski Ron
Pastricha Jay
Pruchnic Ryan
Ridout & Maybee Llp
University Of Pittsburgh
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