Muscle protein proteolysis inhibiting agent containing il-6...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2211578

The present invention provides a muscle protein proteolysis inhibiting agent comprising antibody to Interleukin-6 receptor (IL-6R antibody). Antibodies of animals other than humans such as mice and rats, chimeric antibodies of these antibodies with human antibodies, and reshaped human antibodies and so forth can be used for the IL-6R antibody. The muscle protein proteolysis inhibiting agent of the present invention is useful in the inhibition of muscle protein proteolysis observed in diseases such as cancerous cachexia, sepsis, serious trauma or muscular dystrophy.

La présente invention concerne un agent inhibant la protéolyse des protéines musculaires contenant un anticorps dirigé contre le récepteur de l'interleukine-6 (anticorps anti-IL-6R). Il peut par exemple s'agir d'un anticorps provenant d'un animal autre que l'humain, notamment un anticorps de souris ou de rat, d'un anticorps chimère associant un fragment d'un tel anticorps et un fragment d'un anticorps humain, ou encore d'un anticorps humain remodelé. Cet inhibiteur est utile pour inhiber la protéolyse des protéines musculaires survenant dans diverses affections telles que la cachexie cancéreuse, les septicémies, les traumatismes graves et la dystrophie musculaire.

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