Muscle trophic factor

Details Muscle trophic factor Muscle trophic factor

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 31/56 (2006.01) A61K 38/27 (2006.01) A61K 38/30 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2221148

Compositions and methods for stimulating muscle growth or differentiation in a vertebrate are disclosed. Such compositions include a muscle-trophic amount of interleukin-15 and can be used to treat a variety of conditions including disuse atrophy, wasting, various age-related disorders, secondary effects of diabetes, including glucose-intolerance, as well as muscular dystrophy, rhabdomyosarcoma and congestive heart failure. The compositions and methods of the invention find agricultural use in increasing the efficiency of meat and milk production of farm animals.

L'invention concerne des compositions et des procédés pour stimuler la croissance ou la différentiation musculaire chez les vertébrés. Ces compositions contiennent une quantité suffisante pour avoir un effet trophique d'interleukine-15 et peuvent être utilisées pour traiter différents troubles tels que l'atrophie due à l'inactivité, l'atrophie, différents troubles liés au vieillissement, les effets secondaires du diabète dont l'intolérance au glucose ainsi que la myopathie primitive progressive, le rhabdomyosarcome et l'insuffisance cardiaque congestive. Les compositions et les procédés de l'invention trouvent des applications en agriculture pour augmenter l'efficacité de la production de viande et de lait chez les animaux de ferme.

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