Mutant acidic fibroblast growth factor

Details Mutant acidic fibroblast growth factor Mutant acidic fibroblast growth factor

C - Chemistry, Metallurgy

12

N

195/1.235

C12N 15/12 (2006.01) C07K 14/50 (2006.01)

Patent

CA 1340639

Novel genes coding for mutant bovine and human aFGF are constructed. The unique genes are derived from genes encoding recombinant bovine and human aFGF by specific point mutations. Each gene construct is inserted into an expression vector which is used to transform an appropriate host. The transformed host cells produce unique mutant recombinant aFGF, human or bovine, which is purified and has enhanced or improved biological activity in the absence of heparin compared to the unmutated forms.

617099

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