Mutant actinosynnema pretiosum strain with increased...

Details Mutant actinosynnema pretiosum strain with increased... Mutant actinosynnema pretiosum strain with increased...

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2474639

A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and capable of growth under varied culture conditions, and methods of producing maytansinoid ansamitocins by culturing PF4-4 in a suitable growth medium.

L'invention concerne un micro-organisme se présentant sous la forme d'une souche bactérienne mutante de l'espèce Actinosynnema pretiosum, désignée par PF4-4 (ATCC PTA-3921), pouvant produire des ansamiticines maytansinoïdes telles que l'ansamitocine P-3 à un meilleur rendement que des souches déjà connues, et pouvant se développer sous différentes conditions de culture. L'invention se rapporte en outre à des procédés de production d'ansamitocines maytansinoïdes, par culture de PF4-4 dans un milieu de croissance approprié.

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