Mutant b-raf polypeptide and a use thereof in the diagnosis...

Details Mutant b-raf polypeptide and a use thereof in the diagnosis... Mutant b-raf polypeptide and a use thereof in the diagnosis...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07H 21/04 (2006.01) C07K 16/32 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12P 19/34 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2471114

The invention relates to mutations in B-Raf gene products. The mutations described are identified in human tumours of natural origin. These mutations are associated with cancerous phenotypes and can be used as a basis for the diagnosis of cancer, cancerous cells or a predisposition to cancer in human subjects, and the development of anti-cancer therapeutics.

Cette invention concerne des mutations dans des produits géniques B-Raf. Ces mutations sont identifiées dans des tumeurs humaines d'origine naturelle. Ces mutations sont associées à des phénotypes cancéreux et peuvent servir de base pour diagnostiquer un cancer, des cellules cancéreuses ou une prédisposition au cancer chez des sujets humains, de même que pour élaborer des traitements anticancéreux.

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