A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/00 (2006.01) A61P 31/00 (2006.01) C07K 14/235 (2006.01) C07K 14/245 (2006.01) C07K 14/28 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2519511
The invention relates to a mutant cholera holotoxin having reduced toxicity, which functions both as an adjuvant and an antigen carrier. In a particular embodiment, the cholera holotoxin is genetically modified at least at amino acid residue 29 of the A subunit, wherein the genetic modification comprises an amino acid substitution of the wild-type glutamic acid at position 29, wherein the substitution is not an aspartic acid.
La présente invention concerne une holotoxine de choléra mutante ayant une toxicité limitée, et jouant le rôle à la fois d'adjuvant et de support d'antigène. Dans un mode de réalisation particulier, l'holotoxine de choléra est modifiée génétiquement au moins au niveau du radical d'acide aminé 29 de la sous-unité A, la modification génétique comprenant une substitution d'acide aminé de l'acide glutamique de type sauvage en position 29, la substitution n'étant pas un acide aspartique.
Torys Llp
Wyeth Holdings Corporation
LandOfFree
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