Mutant dna polymerases and related methods

Details Mutant dna polymerases and related methods Mutant dna polymerases and related methods

C - Chemistry, Metallurgy

12

N

C12N 9/12 (2006.01)

Patent

CA 2693657

Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.

La présente invention concerne des ADN polymérases mutantes ayant des taux d'extension améliorés par rapport à une polymérase non modifiée correspondantes. Les polymérases mutantes sont utiles dans une variété de procédés d'extension d'amorces selon l'invention. L'invention concerne également des compositions associées, comprenant des acides nucléiques recombinants, des vecteurs, et des cellules hôtes, qui sont utiles, par exemple, pour la production d'ADN polymérases mutantes.

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