Mutant enterotoxin effective as a non-toxic oral adjuvant

Details Mutant enterotoxin effective as a non-toxic oral adjuvant Mutant enterotoxin effective as a non-toxic oral adjuvant

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/106 (2006.01) A61K 39/108 (2006.01) C07K 14/245 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2198586

Methods and compositions are provided herein for the use of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This enterotoxin is used in combination with an unrelated antigen to achieve an increased immune response to said antigen when adminsitered as part of an oral vaccine preparation.

La présente invention concerne des méthodes et des compositions associées à l'utilisation d'une nouvelle forme mutante de l'entérotoxine thermolabile d'E. coli, laquelle a perdu sa toxicité mais a conservé son activité immunologique. Ladite entérotoxine est utilisée en association avec un antigène non apparenté de façon à induire une réponse immunitaire accrue vis-à-vis dudit antigène lorsqu'elle est administrée dans une préparation vaccinale orale.

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