Mutant forms of cholera holotoxin as an adjuvant

Details Mutant forms of cholera holotoxin as an adjuvant Mutant forms of cholera holotoxin as an adjuvant

A - Human Necessities

61

K

A61K 39/42 (2006.01) A61K 39/39 (2006.01) C07K 14/28 (2006.01)

Patent

CA 2449670

Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.

Dans cette invention, des holotoxines de choléra mutantes comportant des insertions ou des substitutions d'acide aminé simple ou double présentent une toxicité réduite par rapport à l'holotoxine du choléra de type sauvage. Les holotoxines mutantes du choléra sont utilisées comme adjuvants dans des compositions antigéniques pour augmenter la réponse immunitaire chez un hôte vertébré vis à vis d'un antigène sélectionné à partir d'une bactérie pathogène, un virus, un champignon, ou un parasite, une cellule cancéreuse, une cellule tumorale, un allergène ou une molécule du soi.

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