Mutant forms of cholera holotoxin as an adjuvant

Details Mutant forms of cholera holotoxin as an adjuvant Mutant forms of cholera holotoxin as an adjuvant

A - Human Necessities

61

K

A61K 39/42 (2006.01) A61K 39/39 (2006.01) C07K 14/28 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2449663

Mutant cholera holotoxins comprising a cholera toxin subunit (A) having single amino acid substitutions in the amino acid positions (16 or 72) or a double amino acid positions (16 and 68) or (68 and 72) have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self- molecule.

L'invention concerne des holotoxines mutantes du choléra comprenant une sous-unité (A) de la toxine du choléra comprenant des substitutions simples d'acide aminé dans les positions d'acide aminé (16 ou 72) ou des substitutions doubles d'acide aminé dans les positions d'acide aminé (16 et 68) ou (68 et 72). Ces holotoxines possèdent une toxicité réduite par rapport à l'holotoxine du choléra de type sauvage. Ces holotoxines mutantes de choléra sont utiles en tant qu'adjuvants dans des compositions immunogènes permettant d'augmenter la réponse immunitaire, chez un hôte vertébré, à un antigène choisi dans le groupe comprenant bactérie pathogène, virus, champignon, ou parasite, cellule cancéreuse, cellule tumorale, allergène, ou molécule du soi.

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