Mutant glycoproteins

Details Mutant glycoproteins Mutant glycoproteins

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/00 (2006.01) A61K 38/24 (2006.01) A61K 47/48 (2006.01) A61P 15/08 (2006.01) C07K 14/59 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2469724

The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the invention permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.

La présente invention se rapporte à de nouveaux mutants FSH (hormone folliculostimulante) ayant une glycosylation accrue et des demi-vies plus longues qui sont destinés à être utilisés pour induire la folliculogenèse chez des patients humains. L'utilisation d'une préparation de mutant FSH selon l'invention permet d'utiliser des doses cumulées moins importantes de FSH pour obtenir le même résultat clinique ou même un meilleur résultat clinique.

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