Mutant herpes simplex viruses and uses thereof

Details Mutant herpes simplex viruses and uses thereof Mutant herpes simplex viruses and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 15/869 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2328594

A herpes simplex virus (HSV) comprising: (i) an HSV LAT sequence inserted into an essential gene of the HSV; and (ii) a deletion in the endogenous LAT region of the HSV strain. The HSV of the invention can be used in the treatment of disorders of, or injuries to, the nervous system of a mammal.

L'invention concerne un virus de l'herpès simplex (HSV) comprenant: i) une séquence HSV LAT insérée dans un gène essentiel du HSV; et ii) une délétion dans la région LAT endogène de la souche HSV. Le HSV de cette invention peut notamment être utilisé pour traiter les troubles du système nerveux d'un mammifère, ou les lésions au système nerveux d'un mammifère.

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