Mutant human prourokinase

Details Mutant human prourokinase Mutant human prourokinase

C - Chemistry, Metallurgy

12

N

C12N 15/58 (2006.01) C12N 5/10 (2006.01) C12N 9/72 (2006.01) C12N 15/85 (2006.01) H03H 9/36 (2006.01)

Patent

CA 2079992

ABSTRACT OF THE DISCLOSURE A mutant human prourokinase wherein a neutral amino acid in the epidermal growth factor (EGF) region of human prourokinase (human PUK) has been replaced with a basic amino acid, or an acidic amino acid has been replaced with a non-acidic amino acid, and a method for producing a mutant human PUK which comprises expression of mutant human PUK by cultivating a host transformed by a plasmid inserted with a DNA sequence coding for said mutant human PUK. By replacing a neutral amino acid in the EGF region of human PUK which is a fibrinolysin with a basic amino acid, or an acidic amino acid with a non-acidic amino acid, half-life in blood can be prolonged, and affinity for fibrin can be improved.

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