Mutant human t cell line producing immunosuppressive factor...

Details Mutant human t cell line producing immunosuppressive factor... Mutant human t cell line producing immunosuppressive factor...

C - Chemistry, Metallurgy

12

N

150/11, 167/139,

C12N 5/02 (2006.01) C07K 14/52 (2006.01) C12N 5/06 (2006.01) C12N 15/00 (2006.01) C12P 21/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 38/11 (2006.01)

Patent

CA 1228312

MUTANT HUMAN T CELL LINE PRODUCING IMMUNOSUPPRESSIVE FACTOR ABSTRACT A stable mutant human T cell line is disclosed which secretes a high titer suppressor inducer factor. This suppressor inducer factor in turn induces production of a T cell suppressor factor which suppressed mitogen-induced T cell proliferation at high dilution. Also disclosed is a general method for mutating lymphoblastoid cell lines to yield mutants secreting enhanced levels of lymphokines.

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