Mutant il-10

Details Mutant il-10 Mutant il-10

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 38/20 (2006.01) C12N 15/24 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2609543

IL-10 sequence variants are disclosed that retain the therapeutically desirable anti-inflammatory properties of wild-type IL-10 but do not retain the hemoatopoeitic cell regulatory and cell proliferative activities. The mutant IL-10 polypeptides of the invention are used in methods of treating diseases involving inflammatory response, including neuropathic pain and other neurological disorders.

L'invention concerne des variants de séquence d'IL-10 qui conservent les propriétés anti-inflammatoires désirées sur le plan thérapeutique de l'IL-10 de type sauvage sans conserver les activités de régulation des cellules hématopoïétiques et de prolifération cellulaire. Lesdits polypeptides d'IL-10 mutante sont utilisés dans des méthodes de traitement de maladies dans lesquelles la réponse inflammatoire est impliquée, de type douleur neuropathique et autres troubles neurologiques.

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