C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A23C 19/032 (2006.01) C07K 14/315 (2006.01) C12N 9/52 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2391940
The invention relates to mutants of lactic bacteria such as L. lactis or S. thermophilus which can overexpress one or more peptidases, characterised in that at least one of the negative regulation factors of at least one of the peptidase genes of said bacteria is inactivated, said negative regulation factor being selected from a group comprising the gene codY, the genes of the operon lev, and a gene coding for a protein that is homologous with a .beta.-glucosidase.
La présente invention se rapporte à des mutants de bactéries lactiques, comme L. lactis ou S. thermophilus capables de surexprimer une ou plusieurs peptidases, caractérisés en ce que l'un au moins des facteurs de régulation négative de l'un au moins des gènes des peptidases desdites bactéries est inactivé, ledit facteur de régulation négative étant choisi dans le groupe comprenant le gène codY, les gènes de l'opéron lev, un gène codant une protéine homologue à une .beta.-glucosidase.
Anba-Mondoloni Jamila
Delorme Christine
Guedon Eric
Renault Pierre
Gowling Lafleur Henderson Llp
Institut National de La Recherche Agronomique - Inra
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