Mutant ob receptors and nucleotides encoding them

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/12 (2006.01) C07K 14/575 (2006.01) C07K 14/705 (2006.01) C12N 15/63 (2006.01) G01N 33/50 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2273164

Mutant ob receptors have been made which a) lack a functional first CK-F3 domain; b) lack a functional second CK-F3 domain or c) lack a functional intracellular domain. These receptors may be used in various assays, such as a transactivation assay to identify novel ligands.

Ces récepteurs mutants de ob produits au titre de l'invention se caractérisent par: a, une absence d'un premier domaine fonctionnel CK-F3, b, une absence d'un second domaine fonctionnel CK-F3 ou c, une absence d'un domaine fonctionnel intracellulaire. On peut utiliser ces récepteurs dans le cadre de nombreuses épreuves notamment des épreuves de transactivation visant à l'identification de nouveaux ligands.

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