Mutant plk protein and gene encoding the same

Details Mutant plk protein and gene encoding the same Mutant plk protein and gene encoding the same

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2347249

A mutant Plk protein having a mutation in C-terminal domain thereof specified by amino acid residues of from 439 to 603 of amino acid sequence of wild-type Plk protein wherein said mutation decreases affinity with Hsp90 protein, and a gene encoding said mutant Plk protein are provided. A method for detecting an abnormal cell which comprises the step of detecting the mutant Plk protein or the gene encoding the protein is also provided.

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