Mutant proteinase inhibitors and uses thereof

Details Mutant proteinase inhibitors and uses thereof Mutant proteinase inhibitors and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2453810

A library of mutants of metastable proteins, such as proteinase inhibitors, can be screened for the specific loss of a wild-type capability to bind an antibody, yielding valuable drug-design information which otherwise is unavailable. By this approach, for example, a mutant proteinase inhibitor can be obtained that has the amino acid sequence of a wild-type protein, or an active fragment therof, save for the presence of one or more mutations in at least one epitope, thereby altering interaction of the mutant with an anti- proteinase inhibitor antibody.

L'invention concerne une banque de mutants de protéines métastables, tels que des inhibiteurs de protéinases, pouvant être criblée afin de déterminer la perte spécifique d'une capacité de type sauvage de liaison à un anticorps, et ainsi, d'obtenir des informations utiles relatives à la conception de médicaments qui ne peuvent être obtenues autrement. L'approche décrite dans cette invention permet d'obtenir, par exemple, un inhibiteur de protéinase mutant doté d'une séquence d'acides aminés d'une protéine de type sauvage, ou un fragment actif de celui-ci, sauf en présence d'une ou de plusieurs mutations dans au moins un épitope, ce qui modifie l'interaction du mutant et de l'anticorps inhibiteur anti-protéinase.

Affiliated with

Also associated with

Rating

Mutant proteinase inhibitors and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mutant proteinase inhibitors and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant proteinase inhibitors and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1958520