Mutant proteins of the f protein of piv-5 and piv-2

Details Mutant proteins of the f protein of piv-5 and piv-2 Mutant proteins of the f protein of piv-5 and piv-2

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/115 (2006.01)

Patent

CA 2744410

The invention relates to two mutant proteins of the fusion protein (F protein) of the Parainfluenza virus (PIV) currently recorded as type-5 PFV (PIV-5 or PIV5) and type-2 PIV (PIV-2 or PIV2). The present invention relates to products derived therefrom such as: nucleic acids, vectors, cells; fusion inhibitors of the antibody, aptamers, interfering RNA; myelomae, hybridomae, progenitor and stem cells. The present invention also relates to said mutant proteins and products derived therefrom used in medical applications and biotechnologies.

La présente demande est relative à des protéines mutantes - de la protéine de fusion (protéine F) de virus Parainfluenza (PIN) qui sont actuellement répertoriés sous PFV de type 5(PIV-5 ou PIV5) et PIV de type 2(PIV-2 ou PIV2). La présente demande est relative à des produits en dérivant, tels que : - acides nucléiques, vecteurs, cellules; inhibiteurs de fusion de type anticorps, aptamères, ARN interférants; myélomes, hybridomes, cellules souches et progénitrices. La présente demande est également relative à ces protéines mutantes et produits en dérivant pour leur utilisation dans des applications médicales et biotechnologiques.

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