Mutant pseudorabies virus, and vaccines containing the same

Details Mutant pseudorabies virus, and vaccines containing the same Mutant pseudorabies virus, and vaccines containing the same

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/245 (2006.01) C07K 14/03 (2006.01) C12N 9/12 (2006.01) C12N 15/00 (2006.01) C12N 15/38 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2065002

2065002 9102795 PCTABS00003 The invention relates to a pseudorabies virus (PRV) not found in nature and having a genome containing a mutation in the protein kinase gene region and/or in the 28K gene region. The mutation is e.g. a nucleic acid substitution, deletion, insertion or inversion, or a combination thereof. The mutations are introduced, by genetic engineering techniques, into the genome of a naturally occuring PRV, preferably NIA-3. Insertions may be nucleic acid sequences encoding antigenic polypeptides characteristic of a pathogen found in pigs. The invention also relates to vaccines containing a pseudorabies virus according to the invention, and to a process for preparing such vaccines.

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